The science

The Lapex BCS emits low levels laser energy, the fat cell membranes are disrupted releasing intra-cellular fat. This causes the cell to lose its round shape by changing the permeability of the cell membrane. This does not affect the neighboring structures such as skin, blood vessels, and peripheral nerves.

Triglycerides spill out from the broken cell membranes and are released into the interstitial space, where they are slowly transported through the body's natural metabolic functions, with no adverse physiological effects and are used by the body as an energy source. This mechanism of action is not "liquefaction of fat" rather, it is the instant breakdown of the fat cells (also referred to as lypolysis).

Anna Brazier
Meridian Medical Inc.

Re: Mechanism and Safety of the Lapex BCS

I have tried to summarize my understanding of the mechanism by which the Lapex BCS accomplishes local fat reduction and my reasons for believing that the mechanism by which it works is Safe.

Low-level, laser energy disrupts the fat cell membrane. This releases intracellular fat and causes the cell to lose its round shape by changing the permeability of the fat cell membrane (Neira, 2002). The disruption of the fat cell membrane does not affect neighbouring structures such as the skin, blood vessels, or peripheral names (Neira. 2002).

This suggests that the fat is being deposited in the interstitial space between the fat cells. The other mechanism is through the lymphatics, which drain the Interstitial space into the venous system. Triglycerides released through the broken fat cell membranes are deposited into the interstitial cellular space and carried away by the lymphatic system. The lymphatic system drains into the venous system where the released triglycerides are broken down in to free fatty acids and glycerol by lipoprotein lipase. These fatty acids and glycerol are taken up and re-esterified by other fat cells in the body, unless they are burned for fuel. Fat eaten as food is processed into chylomicrons in the gut and absorbed through the gastrointestinal tract into the lymph system, which drains into the venous system. Therefore, the fat released by the Lapex BCS and the fat eaten in the diet, both enter the venous system in a similar manner, from two different sites and are processed from that point in a similar manner.

Since the waist decreases by 0.5 cm with a single treatment, 52 grams of fat are mobilized during a treatment session, if one assumes a waist size of 80 cm and a cylindrical torso. This is the equivalent of 468 kcal of fat. This amount of fat is easily processed by the body from a standard meal. Thus, the body has the ability to process the amount of fat mobilized by a Laser Lipo treatment with a great margin of safety giving reassurance that treatment with the Lapex BCS is safe. The safety of the mechanism of action by which the Lapex BCS gives local fat reduction is consistent with the safety observed using the low level lasers in clinical practice for more than a decade.

Ultimately, the Lapex BCS releases fat from fat cells as triglycerides (energy) that are transported in the body using the normal transport channels for fat and processed metabolically in the normal manner in which fat is processed. This process does not put people at risk for adverse physiological events such as disruption of body functions or injury to organs such as the liver, kidney, lung or pancreas. In fact, the triglycerides released from the fat are used by the body as a primary energy source or are re-esterified into fat cells in other body locations.

I hope this explanation will prove helpful and give reassurance that the observed safety of the low level laser in over a decade of clinical use is consistent with the understanding of human physiology and mirrors the peer-reviewed medical literature concerning the low energy laser.

Frank Greenway, M.D.
Medical Director and Professor
>Clinical Investigator, Lapex BCS.

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